Development of mass spectrometric methods combined with chemometrics in a non-target approach for identification of hitherto unknown PFASs.
Development of a robust and high-throughput approach for screening consumer products.
Determining the release of legacy, alternative and unknown PFASs to the atmosphere and consequences for near- and far-field human exposure.
Development of analytical methods for determination of new known (e.g. PFECA, PFESA, HFPO-dimer and trimer acids, polyfluorinated acids) and unknown PFASs.
Using in vitro human skin equivalent models to characterize the trans-dermal uptake of PFASs from both indoor dust and source materials .
Investigating the impact of legacy and emerging PFAS, as well as human-relevant PFAS mixtures on cholesterol homeostasis and cholesterol synthesis and metabolism.
Development of cell- and organ-on-chip-based metabolomic and lipidomic approaches using human adrenal cortex.
Development and application of methods for assessing legacy and alternative PFASs using the total oxidizable precirsr method in addition to total fluorine concentrations in human plasma.
Assessment of the effects of legacy and replacement PFAS exposure on gene expression and diabetes.
To identify associations between available PFAS concentration data in human serum and corresponding serum lipids and metabolomics data.
Evaluation of innovative treatment techniques for the decomposition and removal of PFASs in stormwater, groundwater, wastewater and landfill leachate.
Development of an innovative technique for in-situ remediation of PFASs contaminated groundwater.
Determining the fate and transport behaviour of PFAS in diverse natural unsaturated soils with and without sorbent amendments.
Biodegradation assays of newly synthesized PFASs and potential PFASs precursors in closed bottle systems, analysis of degradation products.
Determine if fluorinated and non-fluorinated alternatives are safer, more sustainable alternatives to long-chain PFASs in selected consumer products and to propose options for the assessment, regulation and management of alternative PFASs where necessary.