Events

PERFORCE3 Webinar: PFAS and risk of myocardial infarction and stroke // Toxicology brought to justice – the Ronneby trial

  • March 4, 2022
  • 11:00
  • - 12:00
  • Organizer: Karolinska Institutet

Zoom link: https://ki-se.zoom.us/j/61456560961
Presentation #1: Perfluoroalkyl substances and risk of myocardial infarction and stroke
Presentation #2: Toxicology brought to justice – the Ronneby trial

Abstract:
Increased levels of cholesterol is one of the most well-known effects of PFAS exposure. However, the potential to impact public health globally by increasing risk of cardiovascular disease remains unexplored. In the first part of this webinar, Tessa Schillemans will present her recent study of the associations of PFAS exposure with risk of myocardial infarction and/or stroke and subsidiary, with baseline blood lipids. A nested case-control study with first incident myocardial infarction and stroke and matched controls from two Swedish cohorts was investigated. The plasma concentrations of eight PFAS were measured using targeted liquid chromatography-triple quadrupole mass spectrometry. This study indicated that PFAS exposure, although associated with increased cholesterol levels, did not associate with increased risk of myocardial infarction, stroke or their composite endpoint. The findings improve our knowledge on cardiovascular health effects of environmental factors and suggest disturbances in pathways unrelated to cholesterol. The effects on blood lipids was also one of the health effect that were discussed in a recent trial between a highly PFAS-exposed population in the city of Ronneby and the local drinking water producer. Dr Mattias Öberg was called as an expert witness in the trial and will during the webinar provide insight into the trial and present a researchers perspective of tort law.

Speakers:


Tessa Schillemans: PhD student at the Institute of Environmental Medicine, unit of Cardiovascular and Nutritional Epidemiology. Her background is in molecular biology and molecular mechanisms of disease, which she studied in the Netherlands. Her PhD research focuses on investigating the impact of per- and polyfluorinated alkyl substances (PFAS), on cardiovascular disease.


Mattias Öberg: Associated Professor at the Institute of Environmental Medicine, unit of Integrative Toxicology. As researcher and risk assessor he stives to give the scientific support needed to ensure a high level of protection of human health and to promote new approaches for assessment of hazards of chemicals. His main area of research concerns persistent organic pollutants, dose-response modelling, and new approach methods according to the 3Rs.